{"id":453,"date":"2026-10-06T08:02:33","date_gmt":"2026-10-06T08:02:33","guid":{"rendered":"https:\/\/ivfprep.guide\/articles\/?p=453"},"modified":"2026-10-15T08:08:48","modified_gmt":"2026-10-15T08:08:48","slug":"implantation-nausea","status":"publish","type":"post","link":"https:\/\/ivfprep.guide\/articles\/implantation-nausea\/","title":{"rendered":"Implantation Nausea: What the hCG Timeline Actually Shows"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>Implantation nausea is mostly a mismatch of dates. In a 2021 diary study of 256 pregnancies, hCG first rose a median 9 days after ovulation, but nausea began a median 16 days after, and only 5 per cent felt it before day 11. 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day 3 or day 5 transfer, the nausea rates printed on two progesterone labels, and eight dated forum accounts.<\/p>\n\n\n\n<div class=\"msq\" id=\"ms-quiz\" data-slug=\"implantation-nausea\" data-category=\"signs and symptoms\" data-list=\"1\">\n<style>.msq,.msq-hook,.msq-box,.msq-end,.msq-tool{--msq-accent:#1F4E79;--msq-accent-text:#FFFFFF;--msq-line:#CBD8E6;--msq-warn:#B4531A;--msq-muted:#4A5560;--msq-tint:#EEF3F8;--msq-base:#FFFFFF}\n.msq{margin:1.25em 0 1.75em}\n.msq-hook{border-left:3px solid var(--msq-accent);padding:6px 14px;color:var(--msq-muted);font-size:.97em}\n.msq-box{background:var(--msq-tint);border:1px solid var(--msq-line);border-radius:12px;padding:0}\n.msq-box>summary{cursor:pointer;list-style:none;padding:14px 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0 6px;font-size:1.15em}\n.msq-tool p{margin:0 0 10px}\n.msq-tool .msq-note{font-size:.85em;color:var(--msq-muted);margin:10px 0 0}\n.msq-check label{display:flex;gap:10px;align-items:flex-start;padding:9px 0;border-bottom:1px solid var(--msq-line);cursor:pointer;line-height:1.4}\n.msq-check label:last-of-type{border-bottom:0}\n.msq-check input{margin-top:5px;flex:0 0 auto;width:18px;height:18px;accent-color:var(--msq-accent)}\n.msq-check-count{font-weight:700;margin:10px 0 0}\n.msq-verdict-box{margin:12px 0 0;padding:10px 14px;border-radius:8px;background:var(--msq-base);border-left:3px solid var(--msq-warn)}\n.msq-verdict-box[hidden]{display:none}\n.msq-calc{display:grid;grid-template-columns:1fr 1fr;gap:10px 16px}\n.msq-calc label{display:flex;flex-direction:column;gap:4px;font-size:.92em}\n.msq-calc input,.msq-calc select{padding:8px 10px;border:1px solid var(--msq-muted);border-radius:8px;font:inherit;background:#fff}\n.msq-calc-out{grid-column:1 \/ -1;margin-top:6px;padding:12px 14px;background:var(--msq-base);border-radius:8px;border:1px solid var(--msq-line)}\n.msq-calc-out strong{font-size:1.15em}\n.msq-choose label{display:block;padding:9px 12px;margin:0 0 8px;background:var(--msq-base);border:1px solid var(--msq-line);border-radius:8px;cursor:pointer}\n.msq-choose input{margin-right:8px;accent-color:var(--msq-accent)}\n.msq-choice-result{margin-top:10px;padding:12px 14px;background:var(--msq-base);border-left:3px solid var(--msq-accent);border-radius:0 8px 8px 0}\n.msq-choice-result[hidden]{display:none}\n@media (max-width:600px){.msq-calc{grid-template-columns:1fr}}\nh2.wp-block-heading[id]{scroll-margin-top:24px}<\/style>\n<noscript><style>.msq-explain{display:block !important}<\/style><\/noscript>\n<details class=\"msq-box\">\n<summary>Think you already know this? Five questions, one minute.<\/summary>\n<div class=\"msq-body\">\n<p class=\"msq-intro\">Every answer is on this page. Answer from what you know now; the page fills in the rest.<\/p>\n<ol class=\"msq-list\">\n<li class=\"msq-q\" data-q=\"1\" data-answer=\"b\" data-title=\"When does implantation happen, and when does pregnancy nausea start?\" data-section=\"#when-does-implantation-happen-and-when-does-pregnancy-nausea\">\n<p class=\"msq-question\">1. In the 2021 diary study, what was the median time from ovulation to the start of nausea?<\/p>\n<div class=\"msq-options\" role=\"group\" aria-label=\"Question 1 options\"><button type=\"button\" class=\"msq-opt\" data-opt=\"a\">9 days<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"b\">16 days<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"c\">30 days<\/button><\/div>\n<p class=\"msq-explain\" hidden><span class=\"msq-verdict\"><\/span>hCG rose a median 9 days after ovulation, and nausea began a median 16 days after it (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby and colleagues, 2021<\/a>). <a class=\"msq-section\" href=\"#when-does-implantation-happen-and-when-does-pregnancy-nausea\">Read the section<\/a><\/p>\n<\/li>\n<li class=\"msq-q\" data-q=\"2\" data-answer=\"b\" data-title=\"How do those days line up after a day 3 or day 5 transfer?\" data-section=\"#how-do-those-days-line-up-after-a-day-3-or-day-5-transfer\">\n<p class=\"msq-question\">2. About how many days after a day 5 transfer is 16 days past ovulation?<\/p>\n<div class=\"msq-options\" role=\"group\" aria-label=\"Question 2 options\"><button type=\"button\" class=\"msq-opt\" data-opt=\"a\">4 days<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"b\">11 days<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"c\">16 days<\/button><\/div>\n<p class=\"msq-explain\" hidden><span class=\"msq-verdict\"><\/span>A day 5 embryo is about 5 DPO on transfer day, so 16 minus 5 is 11, which puts the median nausea onset around many clinics&#8217; test day (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby and colleagues, 2021<\/a>). <a class=\"msq-section\" href=\"#how-do-those-days-line-up-after-a-day-3-or-day-5-transfer\">Read the section<\/a><\/p>\n<\/li>\n<li class=\"msq-q\" data-q=\"3\" data-answer=\"b\" data-title=\"Why can progesterone cause nausea in the two week wait?\" data-section=\"#why-can-progesterone-cause-nausea-in-the-two-week-wait\">\n<p class=\"msq-question\">3. In the Crinone 8% once daily IVF study printed on the label, what share of women reported nausea?<\/p>\n<div class=\"msq-options\" role=\"group\" aria-label=\"Question 3 options\"><button type=\"button\" class=\"msq-opt\" data-opt=\"a\">2 per cent<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"b\">22 per cent<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"c\">60 per cent<\/button><\/div>\n<p class=\"msq-explain\" hidden><span class=\"msq-verdict\"><\/span>The label reports nausea in 22 per cent of 139 women in that study (<a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=75e97aa1-daa4-45f9-b2e2-1a371302914e&#038;type=display\" target=\"_blank\" rel=\"noopener\">Crinone prescribing information<\/a>). <a class=\"msq-section\" href=\"#why-can-progesterone-cause-nausea-in-the-two-week-wait\">Read the section<\/a><\/p>\n<\/li>\n<li class=\"msq-q\" data-q=\"4\" data-answer=\"b\" data-title=\"Why do so many pages list nausea as a sign of implantation?\" data-section=\"#why-do-so-many-pages-list-nausea-as-a-sign-of-implantation\">\n<p class=\"msq-question\">4. How many of the 256 pregnancies in the 2021 study recorded no nausea or vomiting at all?<\/p>\n<div class=\"msq-options\" role=\"group\" aria-label=\"Question 4 options\"><button type=\"button\" class=\"msq-opt\" data-opt=\"a\">None<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"b\">15<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"c\">128<\/button><\/div>\n<p class=\"msq-explain\" hidden><span class=\"msq-verdict\"><\/span>Nausea or vomiting was recorded in 241 of 256 pregnancies, leaving 15 with none in the weeks they were followed (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby and colleagues, 2021<\/a>). <a class=\"msq-section\" href=\"#why-do-so-many-pages-list-nausea-as-a-sign-of-implantation\">Read the section<\/a><\/p>\n<\/li>\n<li class=\"msq-q\" data-q=\"5\" data-answer=\"a\" data-title=\"When is nausea after a transfer a reason to call the clinic?\" data-section=\"#when-is-nausea-after-a-transfer-a-reason-to-call-the-clinic\">\n<p class=\"msq-question\">5. Which of these does the NHS list as a reason to get help with sickness?<\/p>\n<div class=\"msq-options\" role=\"group\" aria-label=\"Question 5 options\"><button type=\"button\" class=\"msq-opt\" data-opt=\"a\">Being unable to keep food or fluids down for 24 hours<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"b\">Feeling queasy in the morning<\/button><button type=\"button\" class=\"msq-opt\" data-opt=\"c\">Going off coffee<\/button><\/div>\n<p class=\"msq-explain\" hidden><span class=\"msq-verdict\"><\/span>The NHS lists being unable to keep food or fluids down for 24 hours among the signs that need help (<a href=\"https:\/\/www.nhs.uk\/pregnancy\/related-conditions\/common-symptoms\/vomiting-and-morning-sickness\/\" target=\"_blank\" rel=\"noopener\">NHS guidance<\/a>). <a class=\"msq-section\" href=\"#when-is-nausea-after-a-transfer-a-reason-to-call-the-clinic\">Read the section<\/a><\/p>\n<\/li>\n<\/ol>\n<div class=\"msq-result\" hidden><\/div>\n<\/div>\n<\/details>\n<script>(function(){\n  if (window.__msqInit) { return; }\n  window.__msqInit = true;\n  var root = document.getElementById('ms-quiz');\n  if (!root) { return; }\n  var meta = { slug: root.getAttribute('data-slug'), category: root.getAttribute('data-category'),\n               list: root.getAttribute('data-list') || '1' };\n  function qs(el, s){ return el.querySelector(s); }\n  function qsa(el, s){ return Array.prototype.slice.call(el.querySelectorAll(s)); }\n  function track(name, params){\n    try { if (typeof gtag === 'function') { var p = params || {}; p.article = meta.slug; gtag('event', name, p); } } catch (e) {}\n  }\n  function jumpList(missed){\n    if (!missed.length) { return ''; }\n    return '<ul class=\"msq-jump\">' + missed.map(function(q){\n      return '<li><a href=\"' + q.getAttribute('data-section') + '\">' + q.getAttribute('data-title') + '<\/a><\/li>';\n    }).join('') + '<\/ul>';\n  }\n  function emailForm(){\n    return '<div class=\"msq-sub\"><p><strong>Get the next one.<\/strong> We publish new articles on ' + meta.category\n      + ' most weeks and recheck this page on Sundays. 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Calculators carry their own small script. *\/\n  function initTools(){\n    qsa(document, '.msq-check').forEach(function(box){\n      var key = 'msq-check-' + meta.slug + '-' + (box.getAttribute('data-id') || 'x');\n      var boxes = qsa(box, 'input[type=checkbox]'), count = qs(box, '.msq-check-count');\n      var yes = qs(box, '.msq-verdict-yes'), no = qs(box, '.msq-verdict-no');\n      var saved = {};\n      try { saved = JSON.parse(localStorage.getItem(key) || '{}'); } catch (e) {}\n      boxes.forEach(function(cb, i){ if (saved[i]) { cb.checked = true; } });\n      function refresh(){\n        var n = boxes.filter(function(cb){ return cb.checked; }).length, state = {};\n        boxes.forEach(function(cb, i){ if (cb.checked) { state[i] = 1; } });\n        try { localStorage.setItem(key, JSON.stringify(state)); } catch (e) {}\n        if (count) { count.textContent = n + ' of ' + boxes.length + (box.getAttribute('data-verb') || ' done'); }\n        if (yes && no) { yes.hidden = n === 0; no.hidden = n !== 0; }\n      }\n      boxes.forEach(function(cb){ cb.addEventListener('change', function(){ refresh(); track('tool_check', { tool: box.getAttribute('data-id') }); }); });\n      refresh();\n    });\n    qsa(document, '.msq-choose').forEach(function(box){\n      var results = qsa(box, '.msq-choice-result');\n      qsa(box, 'input[type=radio]').forEach(function(r){\n        r.addEventListener('change', function(){\n          results.forEach(function(el){ el.hidden = el.getAttribute('data-for') !== r.value; });\n          track('tool_choose', { tool: box.getAttribute('data-id'), choice: r.value });\n        });\n      });\n    });\n  }\n  \/\/ read progress: how far down the article the reader has scrolled, fired once per quarter\n  (function(){\n    var art = root.closest('article') || root.parentNode, fired = {};\n    function check(){\n      var top = art.getBoundingClientRect().top + window.pageYOffset, h = art.offsetHeight || 1;\n      var seen = (window.pageYOffset + window.innerHeight - top) \/ h * 100;\n      [25, 50, 75, 100].forEach(function(m){ if (seen >= m && !fired[m]) { fired[m] = true; track('read_progress', { percent: m }); } });\n    }\n    window.addEventListener('scroll', check, { passive: true }); window.addEventListener('load', check);\n  })();\n  if (document.readyState === 'loading') { document.addEventListener('DOMContentLoaded', initTools); } else { initTools(); }\n})();<\/script>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"when-does-implantation-happen-and-when-does-pregnancy-nausea\">When does implantation happen, and when does pregnancy nausea start?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The best evidence on the first question is still the 1999 urine study by Wilcox, Baird and Weinberg in the <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM199906103402304\" target=\"_blank\" rel=\"noopener\">New England Journal of Medicine<\/a>: among 141 pregnancies that lasted at least six weeks, hCG, the pregnancy hormone, first appeared 6 to 12 days after ovulation, and on day 8, 9 or 10 in 84 per cent of them. Implantation is the event that starts hCG, so that is the window.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The second question was answered much more recently, and far more precisely. Gadsby and colleagues, publishing in <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">BMC Pregnancy and Childbirth in 2021<\/a>, recruited UK women who were trying to conceive, had them collect daily urine so the lab could date ovulation from the LH surge and catch the first rise of hCG, and asked them to keep a symptom diary from before they knew they were pregnant. That last detail matters. Older studies asked women at their first antenatal appointment, often around 12 weeks, to remember when the sickness began, which is roughly as reliable as asking someone in March when their cold started.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Across 256 pregnancies, hCG rose above 1 mIU\/ml, a laboratory threshold far below anything a pharmacy test reads, a median 9 days after ovulation, and within 8 to 10 days in 88 per cent. Nausea or vomiting was recorded in 241 of the 256. Its onset came a median 16 days after ovulation. Two thirds of those women first felt it between day 11 and day 20, and only 5 per cent before day 11. The earliest onset anyone recorded was day 8.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">So the hormone comes first and the sickness follows, typically a week or so later. That order makes biological sense: the authors link nausea to a specific stage of development at the junction of embryo and womb, which comes after implantation, not during it.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"how-do-those-days-line-up-after-a-day-3-or-day-5-transfer\">How do those days line up after a day 3 or day 5 transfer?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Every number above is counted from ovulation, and after a transfer there is no ovulation day to count from. The conversion is subtraction. An embryo&#8217;s age, counted from egg collection, matches days past ovulation to within about a day, so a day 5 blastocyst is roughly 5 DPO on transfer day and a day 3 embryo roughly 3 DPO. The <a href=\"https:\/\/ivfprep.guide\/articles\/implantation-timeline\/\">implantation timeline after a day 3 or day 5 transfer<\/a> walks through the arithmetic in full; the table below applies it to nausea, with the source on every row.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Days past ovulation<\/th><th>Days past a day 5 transfer<\/th><th>Days past a day 3 transfer<\/th><th>What the published data places here<\/th><\/tr><\/thead><tbody><tr><td>6 DPO<\/td><td>1<\/td><td>3<\/td><td>Earliest first hCG among 141 pregnancies (<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJM199906103402304\" target=\"_blank\" rel=\"noopener\">Wilcox 1999<\/a>)<\/td><\/tr><tr><td>8 DPO<\/td><td>3<\/td><td>5<\/td><td>Earliest nausea onset recorded in 241 diaries (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><tr><td>9 DPO<\/td><td>4<\/td><td>6<\/td><td>Median first rise of hCG; 88 per cent rose on days 8 to 10 (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><tr><td>11 DPO<\/td><td>6<\/td><td>8<\/td><td>Before this day, only 5 per cent had any nausea (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><tr><td>13 DPO<\/td><td>8<\/td><td>10<\/td><td>A quarter had started feeling sick by now (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><tr><td>16 DPO<\/td><td>11<\/td><td>13<\/td><td>Median nausea onset (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><tr><td>20 DPO<\/td><td>15<\/td><td>17<\/td><td>Two thirds had their onset between day 11 and here (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><tr><td>22 DPO<\/td><td>17<\/td><td>19<\/td><td>Three quarters had started by now (<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7786982\/\" target=\"_blank\" rel=\"noopener\">Gadsby 2021<\/a>)<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Days past ovulation converted by subtracting the embryo&#8217;s age on transfer day. Nausea onset from Gadsby and colleagues, 2021, 241 women with symptoms out of 256 pregnancies conceived naturally; first hCG from Wilcox, Baird and Weinberg, 1999. Checked 6 October 2026.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Read down the day 5 column and the shape is plain. In the first week after a blastocyst transfer, the data puts very little pregnancy nausea anywhere: the median onset lands 11 days after transfer, which for many clinics is around test day itself. Two honest caveats. These were natural conceptions, not IVF, and no equivalent diary study after transfer turned up in this research. And a range across 241 women says nothing about where one person sits on it.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1600\" height=\"900\" src=\"https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/implantation-nausea-chart.png\" alt=\"Timeline of implantation nausea onset against the first rise of hCG, in days past ovulation\" class=\"wp-image-455\" srcset=\"https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/implantation-nausea-chart.png 1600w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/implantation-nausea-chart-300x169.png 300w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/implantation-nausea-chart-1024x576.png 1024w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/implantation-nausea-chart-768x432.png 768w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/implantation-nausea-chart-1536x864.png 1536w\" sizes=\"auto, (max-width: 1600px) 100vw, 1600px\" \/><figcaption class=\"wp-block-image__caption\">First hCG from Wilcox, Baird and Weinberg, 1999; hCG rise and nausea onset from Gadsby and colleagues, 2021, 256 pregnancies conceived naturally. Checked 6 October 2026.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"why-can-progesterone-cause-nausea-in-the-two-week-wait\">Why can progesterone cause nausea in the two week wait?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Because nausea is a listed side effect of the progesterone that supports nearly every transfer, and it starts on its own schedule, not the embryo&#8217;s. The prescribing labels give the numbers from the trials that licensed each product.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1376\" height=\"768\" src=\"https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/bedside-table-medication-mimicking-implantation-nausea.jpg\" alt=\"A bedside table with a glass of water, unmarked capsules and a notebook, the progesterone side of implantation nausea.\" class=\"wp-image-451\" srcset=\"https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/bedside-table-medication-mimicking-implantation-nausea.jpg 1376w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/bedside-table-medication-mimicking-implantation-nausea-300x167.jpg 300w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/bedside-table-medication-mimicking-implantation-nausea-1024x572.jpg 1024w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/bedside-table-medication-mimicking-implantation-nausea-768x429.jpg 768w\" sizes=\"auto, (max-width: 1376px) 100vw, 1376px\" \/><figcaption class=\"wp-block-image__caption\">Nausea is a listed side effect of the progesterone used after transfer.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th>Product and study<\/th><th>Women<\/th><th>Reported nausea<\/th><\/tr><\/thead><tbody><tr><td><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2ba50fa9-b349-40cb-9a4b-1af8faa4ec09\" target=\"_blank\" rel=\"noopener\">Endometrin label<\/a>, 100 mg twice daily, ART study<\/td><td>404<\/td><td>32, or 8 per cent<\/td><\/tr><tr><td><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=2ba50fa9-b349-40cb-9a4b-1af8faa4ec09\" target=\"_blank\" rel=\"noopener\">Endometrin label<\/a>, 100 mg three times daily, same study<\/td><td>404<\/td><td>29, or 7 per cent<\/td><\/tr><tr><td><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=75e97aa1-daa4-45f9-b2e2-1a371302914e&#038;type=display\" target=\"_blank\" rel=\"noopener\">Crinone 8% label<\/a>, once daily, IVF luteal support<\/td><td>139<\/td><td>22 per cent, with vomiting in 5 per cent<\/td><\/tr><tr><td><a href=\"https:\/\/dailymed.nlm.nih.gov\/dailymed\/fda\/fdaDrugXsl.cfm?setid=75e97aa1-daa4-45f9-b2e2-1a371302914e&#038;type=display\" target=\"_blank\" rel=\"noopener\">Crinone 8% label<\/a>, twice daily, donor egg transfer<\/td><td>61<\/td><td>7 per cent<\/td><\/tr><\/tbody><\/table><figcaption class=\"wp-element-caption\">Treatment emergent adverse events as printed on the US prescribing labels. Checked 6 October 2026.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">These figures need one warning label of their own. The Endometrin study ran for 10 weeks and the women in it included those who became pregnant and those who did not, alongside egg collection pain and ovarian hyperstimulation. So the label numbers blend medication, procedure and pregnancy into one column. That is not a flaw in this page&#8217;s argument; it is the argument. If a drug company with 808 women on its product and a trial protocol cannot separate progesterone nausea from pregnancy nausea, a person on day 4 after transfer cannot either. Back pain gets the same blame on the forums, and the page on <a href=\"https:\/\/ivfprep.guide\/articles\/lower-back-ache-implantation\/\">what the labels record about lower back ache and implantation<\/a> finds it missing from the IVF trials altogether. Bloating lands in the same mixed column, and the page on <a href=\"https:\/\/ivfprep.guide\/articles\/bloating-and-implantation\/\">why bloating says nothing about implantation, and the kind clinics want reported<\/a> sets the leaflet figures beside the OHSS warning list.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The same overlap runs through the rest of the list. This site&#8217;s guides to <a href=\"https:\/\/ivfprep.guide\/articles\/diarrhea-and-implantation\/\">diarrhoea and implantation<\/a> and <a href=\"https:\/\/ivfprep.guide\/articles\/signs-of-implantation\/\">signs of implantation after a transfer<\/a> found the same pattern for gut symptoms, sore breasts and cramps: the medication produces them in cycles that work and cycles that do not. What your own medication may cause is a question for your clinic, which knows your protocol; this page does not. Headaches follow the same pattern, and the placebo groups in the hormone trials show <a href=\"https:\/\/ivfprep.guide\/articles\/headache-and-implantation\/\">why a headache after transfer cannot be read either way<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"why-do-so-many-pages-list-nausea-as-a-sign-of-implantation\">Why do so many pages list nausea as a sign of implantation?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mostly because implantation and early pregnancy get folded into one list. Several of the pages that rank for this search put nausea among the signs of implantation, then say a few lines later that morning sickness usually starts weeks into a pregnancy. Both statements cannot describe the same day. At least one borrows the 11 to 20 day figure from the 2021 study, which is the window for nausea onset, and sets it beside implantation, which that same study dates about a week earlier.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is also a survivorship problem on the forums, where these lists are born. Someone who felt queasy on day 5 and then got a positive result posts about the queasiness. Someone who felt queasy and got a negative is less likely to come back to it, and someone who felt nothing at all and got a positive has nothing to post. The 2021 diaries show that last group is real: 15 of the 256 pregnancies recorded no nausea or vomiting at all in the weeks they were followed. <a href=\"https:\/\/ivfprep.guide\/articles\/successful-implantation-without-bleeding\/\">Successful transfers with no symptoms<\/a> are common, and invisible for exactly that reason. The guide to <a href=\"https:\/\/ivfprep.guide\/articles\/conception-symptoms-before-implantation\/\">conception symptoms before implantation<\/a> traces the same effect for the days before the window opens.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"what-do-people-on-ivf-forums-report-about-nausea\">What do people on IVF forums report about nausea?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">To see whether the accounts match the dates, we read three public Mumsnet threads from April 2023, October 2023 and March 2025, about 55 posts in all, and picked out every post that mentioned nausea or having no symptoms. These are what people report, summarised in our words, not findings.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1376\" height=\"768\" src=\"https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/couple-reading-online-forums-about-implantation-nausea.jpg\" alt=\"A couple on a sofa read a tablet together, comparing forum accounts of implantation nausea.\" class=\"wp-image-452\" srcset=\"https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/couple-reading-online-forums-about-implantation-nausea.jpg 1376w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/couple-reading-online-forums-about-implantation-nausea-300x167.jpg 300w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/couple-reading-online-forums-about-implantation-nausea-1024x572.jpg 1024w, https:\/\/ivfprep.guide\/articles\/wp-content\/uploads\/2026\/10\/couple-reading-online-forums-about-implantation-nausea-768x429.jpg 768w\" sizes=\"auto, (max-width: 1376px) 100vw, 1376px\" \/><figcaption class=\"wp-block-image__caption\">Forums over represent people who felt something; nobody posts about feeling nothing.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">In <a href=\"https:\/\/www.mumsnet.com\/talk\/infertility\/4793941-2dp5dt-who-else-is-in-2ww\" target=\"_blank\" rel=\"noopener\">an April 2023 thread<\/a> started two days after a day 5 transfer, one poster on Cyclogest and Lubion described nausea and tender breasts from around two days after transfer and put both down to the progesterone. Two days after a blastocyst transfer is about 7 DPO, before the earliest onset in the 2021 diaries. Another poster in the same thread reported barely any symptoms at all.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In <a href=\"https:\/\/www.mumsnet.com\/talk\/infertility\/4920537-anyone-in-tww-after-fet\" target=\"_blank\" rel=\"noopener\">an October 2023 thread<\/a> about the wait after a frozen transfer, a poster who went on to test positive attributed what she felt to her medication, which included two progesterone products and steroids. Another recalled feeling sick in an earlier cycle that had not continued.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In <a href=\"https:\/\/www.mumsnet.com\/talk\/infertility\/5301265-bfp-after-ivf-2025\" target=\"_blank\" rel=\"noopener\">a March 2025 thread<\/a> for people newly pregnant after IVF, one poster at nine weeks described nausea that began around week 5, the timing the diary study would predict. Another, at about five weeks, reported nothing beyond tiredness. A third, newly positive, was nauseous and exhausted and thought some of it was probably the Cyclogest.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That is eight relevant accounts, ranging from strong nausea to none, and in both outcome groups. Where they agree with the evidence: posters who felt sick within days of transfer mostly blamed the progesterone, and the one who dated a pregnancy onset put it at about week 5. Where they part company with it: the threads still treat each twinge as worth reporting, and nobody reports the cycles where nothing happened.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"when-is-nausea-after-a-transfer-a-reason-to-call-the-clinic\">When is nausea after a transfer a reason to call the clinic?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When it comes with other symptoms, or when you cannot keep fluids down. After a fresh cycle, nausea and vomiting are among the symptoms of ovarian hyperstimulation syndrome listed by <a href=\"https:\/\/www.guysandstthomas.nhs.uk\/health-information\/ivf-treatment\/risks-ivf\" target=\"_blank\" rel=\"noopener\">Guy&#8217;s and St Thomas&#8217; fertility unit<\/a>, alongside tummy pain and swelling, passing small amounts of dark urine, thirst, diarrhoea, dizziness and shortness of breath. The unit says it can develop after egg collection or transfer, and asks anyone with these symptoms to contact them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The <a href=\"https:\/\/www.nhs.uk\/pregnancy\/related-conditions\/common-symptoms\/vomiting-and-morning-sickness\/\" target=\"_blank\" rel=\"noopener\">NHS guidance on sickness in pregnancy<\/a> lists the signs that mean you need help, including very dark urine or none for 8 hours, being unable to keep food or fluids down for 24 hours, feeling dizzy or faint when you stand, tummy pain, a high temperature or vomiting blood. Those signs matter in the two week wait too, whatever is causing the sickness.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you have any of them, or anything else that worries you, call your clinic. They know your protocol, your medication and your history, and this page does not. The date that answers the question underneath all of this is the test date they gave you, and the guide to <a href=\"https:\/\/ivfprep.guide\/articles\/home-pregnancy-test-after-ivf\/\">home pregnancy tests after IVF<\/a> explains why testing early can mislead.<\/p>\n\n\n\n\n\n<div class=\"msq-tool\" id=\"ivf-clinic-call-log\">\n<h3>Clinic call log<\/h3>\n<p>If you ring your clinic during the wait, note the date, what you asked and what they told you, so the answer is in one place at two in the morning.<\/p>\n<div class=\"msq-calc\">\n<label>Date of call<input type=\"date\" name=\"date\"><\/label>\n<label>What you rang about<input type=\"text\" name=\"asked\"><\/label>\n<label>What the clinic said<input type=\"text\" name=\"said\"><\/label>\n<label>Next date they gave you<input type=\"date\" name=\"next\"><\/label>\n\n<div class=\"msq-calc-out\"><button type=\"button\" class=\"msq-btn\" id=\"ivf-clinic-call-log-add\">Add this entry<\/button> <a href=\"#\" class=\"msq-no\" id=\"ivf-clinic-call-log-clear\">Clear all<\/a>\n<div id=\"ivf-clinic-call-log-list\" style=\"margin-top:10px;overflow-x:auto\"><\/div><\/div>\n<\/div>\n<p class=\"msq-note\">This only records what your clinic told you. It does not track or interpret symptoms, and it stays in this browser.<\/p>\n<\/div>\n<script>\n(function(){\n  var root = document.getElementById('ivf-clinic-call-log'); if (!root) { return; }\n  var names = ['date','asked','said','next'], key = 'msq-log-implantation-nausea-ivf-clinic-call-log';\n  var ins = names.map(function(n){ return root.querySelector('[name=\"' + n + '\"]'); });\n  var list = document.getElementById('ivf-clinic-call-log-list');\n  function load(){ try { return JSON.parse(localStorage.getItem(key) || '[]'); } catch (e) { return []; } }\n  function save(rows){ try { localStorage.setItem(key, JSON.stringify(rows)); } catch (e) {} }\n  function esc(s){ return String(s).replace(\/&\/g, '&amp;').replace(\/<\/g, '&lt;').replace(\/>\/g, '&gt;'); }\n  function render(){\n    var rows = load();\n    if (!rows.length) { list.innerHTML = '<p class=\"msq-note\">Nothing logged yet.<\/p>'; return; }\n    var h = '<table><thead><tr><th>Date of call<\/th><th>What you rang about<\/th><th>What the clinic said<\/th><th>Next date they gave you<\/th><\/tr><\/thead><tbody>';\n    rows.slice(0, 30).forEach(function(r){ h += '<tr>' + names.map(function(n){ return '<td>' + esc(r[n] || '') + '<\/td>'; }).join('') + '<\/tr>'; });\n    list.innerHTML = h + '<\/tbody><\/table><p class=\"msq-note\">' + rows.length + ' entries, newest first.<\/p>';\n  }\n  document.getElementById('ivf-clinic-call-log-add').addEventListener('click', function(){\n    var r = {}; var any = false;\n    ins.forEach(function(el, i){ r[names[i]] = el ? el.value : ''; if (el && el.value) { any = true; } });\n    if (!any) { return; }\n    var rows = load(); rows.unshift(r); save(rows); render();\n    ins.forEach(function(el){ if (el && el.type !== 'date') { el.value = ''; } });\n    try { if (typeof gtag === 'function') { gtag('event', 'tool_log', { tool: 'ivf-clinic-call-log', article: 'implantation-nausea' }); } } catch (e) {}\n  });\n  document.getElementById('ivf-clinic-call-log-clear').addEventListener('click', function(e){ e.preventDefault(); save([]); render(); });\n  render();\n})();\n<\/script>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"frequently-asked-questions\">Frequently asked questions<\/h2>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list \">\n<div id=\"faq-q-1\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Can you feel sick on the day of implantation?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No study has measured a sensation on the day of implantation, because nothing marks that day outside a laboratory. In the 2021 diary study, the earliest recorded nausea onset was 8 days after ovulation and only 5 per cent began before day 11.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-q-2\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Is nausea at 5 days past a day 5 transfer a pregnancy symptom?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>It cannot be told apart. Five days after a day 5 transfer is about 10 DPO, before most recorded pregnancy nausea, and progesterone lists nausea as a side effect. Neither its presence nor its absence says anything about the result.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-q-3\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does nausea in the two week wait come from the progesterone?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>It can. The prescribing labels report nausea in 7 to 22 per cent of women in the trials, which included both pregnant and non pregnant women. Whether it is the medication in your case is a question for your clinic.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-q-4\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Does having no nausea mean the transfer has not worked?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>No. In the 2021 study, 15 of 256 pregnancies recorded no nausea at all, and for most of the rest it began after the usual test day. An absence of nausea during the wait is the ordinary picture in either outcome.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-q-5\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Is nausea after a frozen transfer different from after a fresh one?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>The timing of any pregnancy nausea follows embryo age either way. A fresh cycle adds the possibility of ovarian hyperstimulation, where nausea with a swollen tummy or reduced urine is a reason to call the clinic.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-q-6\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question \">Why do symptom lists online include implantation nausea?<\/h3>\n<div class=\"rank-math-answer \">\n\n<p>Many lists merge implantation and early pregnancy into one set of signs, and forums over represent people who felt something and got a positive. The dated studies place pregnancy nausea about a week after the first rise of hCG.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n\n\n<div class=\"msq-end\" id=\"ms-quiz-end\">\n<p><strong>Finished the page?<\/strong> The same five questions from the top, to see what stuck.<\/p>\n<button type=\"button\" class=\"msq-btn msq-start-test\">Test Your Understanding of This Article<\/button>\n<div class=\"msq-mount\"><\/div>\n<\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><em>This article is general information, not medical advice, and is not a substitute for care from a qualified healthcare professional. Speak to your doctor about your own situation.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pregnancy nausea starts about a week after hCG first rises, and progesterone causes nausea too. The dates, converted to days past transfer, row by row.<\/p>\n","protected":false},"author":1,"featured_media":450,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","rank_math_title":"Implantation Nausea: What the hCG Timeline Actually Shows","rank_math_description":"Implantation nausea is mostly a mismatch of dates: hCG rises about 9 days after ovulation, but pregnancy nausea starts a median 16 days after.","rank_math_focus_keyword":"implantation nausea","rank_math_canonical_url":"","rank_math_breadcrumb_title":"","rank_math_facebook_title":"","rank_math_facebook_description":"","rank_math_facebook_image":"","rank_math_twitter_title":"","rank_math_twitter_description":"","rank_math_twitter_image":"","rank_math_pillar_content":"","rank_math_robots":[],"rank_math_advanced_robots":[]},"categories":[3],"tags":[],"class_list":["post-453","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-signs-and-symptoms"],"_links":{"self":[{"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/posts\/453","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/comments?post=453"}],"version-history":[{"count":9,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/posts\/453\/revisions"}],"predecessor-version":[{"id":627,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/posts\/453\/revisions\/627"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/media\/450"}],"wp:attachment":[{"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/media?parent=453"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/categories?post=453"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ivfprep.guide\/articles\/wp-json\/wp\/v2\/tags?post=453"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}